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【结 构 式】 
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【分子编号】51549 【品名】3-Oxosulfolane 【CA登记号】 |
【 分 子 式 】C4H6O3S 【 分 子 量 】134.15584 【元素组成】C 35.81% H 4.51% O 35.78% S 23.9% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The Hantzsch reaction between 3-oxotetrahydrothiophene-1,1-dioxide (I), 3-bromo-4-fluorobenzaldehyde (II) and 3-amino-2-cyclohexen-1-one (III) in refluxing EtOH yielded the hydroxy tetrahydropyridine derivative (IV). Dehydration of the cyclic hemiaminal function of (IV) was carried out in refluxing toluene to produce the racemic dihydropyridine, which was resolved into the individual enantiomers by chiral HPLC.
| 【1】 Drizin, I.; et al.; Novel sulfonyldihydropyridine potassium channel openers with potential utility in the treatment of overactive bladder (OAB). 222nd ACS Natl Meet (Aug 26 2001, Chicago) 2001, Abst MEDI 197. |
| 【2】 Drizin, I.; Holladay, M.W.; Carroll, W.A.; Zhang, H.Q.; Sullivan, J.P. (Abbott Laboratories Inc.); Potassium channel openers. EP 1040097; US 6265417; WO 9931059 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 51549 | 3-Oxosulfolane | C4H6O3S | 详情 | 详情 | |
| (II) | 51550 | 3-Bromo-4-fluorobenzaldehyde | 77771-02-9 | C7H4BrFO | 详情 | 详情 |
| (III) | 31475 | 3-amino-2-cyclohexen-1-one | 5220-49-5 | C6H9NO | 详情 | 详情 |
| (IV) | 51551 | 9-(3-bromo-4-fluorophenyl)-3a-hydroxy-2,3,3a,5,6,7,9,9a-octahydro-1H-2H-thieno[3,2-b]quinoline-1,1,8(4H)-trione | C17H17BrFNO4S | 详情 | 详情 |
Extended Information