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【结 构 式】 
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【分子编号】51505 【品名】N-[4-(4-pyridinylmethyl)phenyl]-1H-imidazole-1-carboxamide 【CA登记号】 |
【 分 子 式 】C16H14N4O 【 分 子 量 】278.31352 【元素组成】C 69.05% H 5.07% N 20.13% O 5.75% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)4-(4-Pyridinylmethyl)aniline (II) was prepared by catalytic hydrogenation of the corresponding nitro derivative (I) over Pd/C. Condensation of aniline (II) with N,N'-carbonyldiimidazole produced the imidazolide (III). This was then condensed with 5-amino-3-tert-butyl-1-methylpyrazole (IV) to furnish the target urea.
| 【1】 Riedl, B.; Lee, W.; Lowinger, T.B.; Redman, A.; Smith, R.A.; Khire, U.; Dumas, J.; Scott, W.J.; Wood, J.E.; Johnson, J.; Paulsen, H.; Hatoum-Mokdad, H. (Bayer Corp.); Inhibition of p38 kinase activity using substd. heterocyclic ureas. WO 9932111 . |
| 【2】 Redman, A.; Paulsen, H.; Lowinger, T.B.; Dumas, J.; Johnson, J.; Wood, J.E.; Scott, W.J.; Khire, U.; Hatoum-Mokdad, H.; Lee, W.; Smith, R.A.; Riedl, B. (Bayer Corp.); Inhibition of raf kinase using substd. heterocyclic ureas. EP 1047418; WO 9932106 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 51503 | 4-(4-Nitrobenzyl)pyridine; 4-(p-nitrobenzyl) pyridine | 1083-48-3 | C12H10N2O2 | 详情 | 详情 |
| (II) | 51504 | 4-(4-pyridinylmethyl)aniline; 4-(4-pyridinylmethyl)phenylamine | C12H12N2 | 详情 | 详情 | |
| (III) | 51505 | N-[4-(4-pyridinylmethyl)phenyl]-1H-imidazole-1-carboxamide | C16H14N4O | 详情 | 详情 | |
| (IV) | 51506 | 5-Amino-3-tert-butyl-1-methylpyrazole | 118430-73-2 | C8H15N3 | 详情 | 详情 |
Extended Information