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【结 构 式】

【分子编号】51474

【品名】N-methoxy-N-methyl-2-phenyl-1H-imidazole-4-carboxamide

【CA登记号】

【 分 子 式 】C12H13N3O2

【 分 子 量 】231.25424

【元素组成】C 62.33% H 5.67% N 18.17% O 13.84%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

The hydrolysis of 2-phenyl-4-(trifluoromethyl)-1H-imidazole (I) with 1N NaOH gives 2-phenyl-1H-imidazole-4-carboxylic acid (II), which is condensed with N,O-dimethylhydroxylamine (III) by means of TBTU and DIEA in dichloromethane to yield the amide (IV). The reduction of (IV) with DIBAL in THF affords 2-phenyl-1H-imidazole-4-carbaldehyde (V), which is finally condensed with N-tert-butylhydroxylamine (VI) by means of NaHCO3 in hot ethanol to provide the target nitrone.

1 Dhainaut, A.; et al.; Synthesis, structure, and neuroprotective properties of novel imidazolyl nitrones. J Med Chem 2000, 43, 11, 2165.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 35452 2-phenyl-4-(trifluoromethyl)-1H-imidazole C10H7F3N2 详情 详情
(II) 51473 2-phenyl-1H-imidazole-4-carboxylic acid C10H8N2O2 详情 详情
(III) 13361 (Methoxyamino)methane; N,O-Dimethylhydroxylamine 1117-97-1 C2H7NO 详情 详情
(IV) 51474 N-methoxy-N-methyl-2-phenyl-1H-imidazole-4-carboxamide C12H13N3O2 详情 详情
(V) 35454 2-phenyl-1H-imidazole-4-carbaldehyde C10H8N2O 详情 详情
(VI) 35455 N-(tert-butyl)hydroxylamine; 2-(hydroxyamino)-2-methylpropane C4H11NO 详情 详情
Extended Information