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【结 构 式】

【分子编号】51471

【品名】methyl (1S,17R)-3-[[(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl)methyl]sulfonyl]-17-(2-methoxyethyl)-3,13-diazapentacyclo[13.3.1.0(2,10).0(4,9).0(13,18)]nonadeca-2(10),4,6,8-tetraene-1-carboxylate

【CA登记号】

【 分 子 式 】C32H42N2O6S

【 分 子 量 】582.76136

【元素组成】C 65.95% H 7.26% N 4.81% O 16.47% S 5.5%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(-)(+)-(II)

The condensation of (rac?-18-methoxycoronaridine with (S)-(+)-camphorsulfonyl chloride (II) by means of KHMDS in THF gives the corresponding mixture of the diastereomeric sulfonamides (-)-(+)-(III) and (+)-(+)-(III), which are separated by normal phase silica gel chromatography. Both diastereomers are treated with KOH in methanol, yielding the target (-)- and (+)-enantiomers.

1 Herr, R.J.; Maisonneuve, I.M.; King, C.-H.R.; Meckler, H.; Glick, S.D.; Trova, M.P.; Synthesis of enantiomerically pure (+)- and (-)-18-methoxycoronaridine hydrochloride and their preliminary assessment as anti-addictive agents. Bioorg Med Chem Lett 2000, 10, 5, 473.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(+)-(II) 18713 (7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl)methanesulfonyl chloride C10H15ClO3S 详情 详情
(-)(+)-(II) 51471 methyl (1S,17R)-3-[[(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl)methyl]sulfonyl]-17-(2-methoxyethyl)-3,13-diazapentacyclo[13.3.1.0(2,10).0(4,9).0(13,18)]nonadeca-2(10),4,6,8-tetraene-1-carboxylate C32H42N2O6S 详情 详情
(+)(+)-(II) 51472 methyl (1R,17S)-3-[[(7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl)methyl]sulfonyl]-17-(2-methoxyethyl)-3,13-diazapentacyclo[13.3.1.0(2,10).0(4,9).0(13,18)]nonadeca-2(10),4,6,8-tetraene-1-carboxylate C32H42N2O6S 详情 详情
(I) 51470 methyl (1S,17R)-17-(2-methoxyethyl)-3,13-diazapentacyclo[13.3.1.0(2,10).0(4,9).0(13,18)]nonadeca-2(10),4,6,8-tetraene-1-carboxylate C22H28N2O3 详情 详情
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