(3bS,4aS,5aS,6S,6aR,7aS,7bS,8aS,8bS)-6-hydroxy-6a-isopropyl-8b-methyl-3b,4,4a,6,6a,7a,7b,8b,9,10-decahydrotrioxireno[2',3':6,7:2',3':8a,9:2',3':4b,5]phenanthro[1,2-c]furan-1(3H)-one -Drug Synthesis Database

【结构式】

【分子编号】51397

【品名】(3bS,4aS,5aS,6S,6aR,7aS,7bS,8aS,8bS)-6-hydroxy-6a-isopropyl-8b-methyl-3b,4,4a,6,6a,7a,7b,8b,9,10-decahydrotrioxireno[2',3':6,7:2',3':8a,9:2',3':4b,5]phenanthro[1,2-c]furan-1(3H)-one

【CA登记号】

【分子式】C₂₀H₂₄O₆

【分子量】360.40696

【元素组成】C 66.65% H 6.71% O 26.64%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The title compound is a semisynthetic derivative of triptolide (I), a substance isolated from the root xylem of the Chinese medicinal plant Tripterygium wilfordii. Condensation of (I) with succinic anhydride (II) in hot pyridine furnished the corresponding hemisuccinate ester. This was converted to the corresponding sodium salt by treatment with aqueous NaHCO3 and then isolated by lyophilization of the filtered solution.

参考文献中间体

合成目标

【1】 Qi, Y.M.; Musser, J.H.; Fidler, J.M. (Pharmagenesis, Inc.); Immunosuppressive cpds. and methods. EP 0907652; JP 2001504437; US 5663335; US 5962516; WO 9731920; WO 9731921 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	51397	(3bS,4aS,5aS,6S,6aR,7aS,7bS,8aS,8bS)-6-hydroxy-6a-isopropyl-8b-methyl-3b,4,4a,6,6a,7a,7b,8b,9,10-decahydrotrioxireno[2',3':6,7:2',3':8a,9:2',3':4b,5]phenanthro[1,2-c]furan-1(3H)-one		C₂₀H₂₄O₆	详情	详情
(II)	11291	Dihydro-2,5-furandione; Succinic anhydride	108-30-5	C₄H₄O₃	详情	详情

Extended Information