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【结 构 式】 
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【分子编号】51394 【品名】(2R)-1-(1H-imidazol-4-yl)-2-propanamine; (1R)-2-(1H-imidazol-4-yl)-1-methylethylamine 【CA登记号】 |
【 分 子 式 】C6H11N3 【 分 子 量 】125.17356 【元素组成】C 57.57% H 8.86% N 33.57% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)Treatment of p-nitrophenol (I) with 1-chloroethyl chloroformate (II) in the presence of pyridine afforded carbonate (III). Subsequent displacement of the chlorine atom of (III) with mercuric acetate in HOAc provided the acetoxy derivative (IV). This was then condensed with (R)-alpha-methylhistamine (V) in HMPT to furnish the title compound.
| 【1】 Stark, H.; et al.; Enzyme-catalyzed prodrug approaches for the histamine H3-receptor agonist (R)-alpha-methylhistamine. Bioorg Med Chem 2001, 9, 1, 191. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11236 | 4-Nitrophenol; p-Nitrophenol | 100-02-7 | C6H5NO3 | 详情 | 详情 |
| (II) | 22014 | 1-chloro-1-[(chlorocarbonyl)oxy]ethane | 50893-53-3 | C3H4Cl2O2 | 详情 | 详情 |
| (III) | 51393 | 1-chloroethyl 4-nitrophenyl carbonate | C9H8ClNO5 | 详情 | 详情 | |
| (IV) | 50378 | 1-[[(4-nitrophenoxy)carbonyl]oxy]ethyl acetate | C11H11NO7 | 详情 | 详情 | |
| (V) | 51394 | (2R)-1-(1H-imidazol-4-yl)-2-propanamine; (1R)-2-(1H-imidazol-4-yl)-1-methylethylamine | C6H11N3 | 详情 | 详情 |
Extended Information