4-chloro-6-quinazolinylamine; 4-chloro-6-quinazolinamine -Drug Synthesis Database

【结构式】

【分子编号】51234

【品名】4-chloro-6-quinazolinylamine; 4-chloro-6-quinazolinamine

【CA登记号】

【分子式】C₈H₆ClN₃

【分子量】179.60856

【元素组成】C 53.5% H 3.37% Cl 19.74% N 23.4%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

Arylamine (I) is converted into the corresponding methyltriazene (II) by formation of the corresponding diazonium salt with NaNO2 in HCl/H2O, followed by reaction with methylamine. Finally, the target compound is obtained by coupling of (II) with the corresponding amine in refluxing isopropanol.

参考文献中间体

合成目标

【1】 Vaughan, K.; et al.; Studies of the model of action of antitumor triazenes and triazines. 6. 1-Ayl-3-(hydroxymethyl)-3-methyltriazenes: Synthesis, chemistry, and antitumor properties. J Med Chem 1984, 27, 3, 357.
【2】 Rewcastle, G.W.; et al.; Tyrosine kinase inhibitors. 5. Synthesis and structure-activity relationships for 4-[(phenylmethyl)amino]- and 4-(phenylamino)quinazolines as potent adenosine 5'-triphosphate binding site inhibitors of the tyrosine kinase domain of the epidermal growth f. J Med Chem 1995, 38, 18, 3482.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	51234	4-chloro-6-quinazolinylamine; 4-chloro-6-quinazolinamine		C₈H₆ClN₃	详情	详情
(II)	51235	4-chloro-6-[(E)-3-methyl-1-triazenyl]quinazoline		C₉H₈ClN₅	详情	详情
(III)	30687	3-methylphenylamine; m-toluidine	108-44-1	C₇H₉N	详情	详情

Extended Information