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【结 构 式】 
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【分子编号】51162 【品名】N'-[(Z)-1-((2S,4S)-4-[[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-2-naphthacenyl)-2-hydroxyethylidene]-4-methylbenzenesulfonohydrazide 【CA登记号】 |
【 分 子 式 】C34H37N3O12S 【 分 子 量 】711.7468 【元素组成】C 57.38% H 5.24% N 5.9% O 26.97% S 4.51% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)Adriamycin hydrochloride (I) was converted to the tosylhydrazone (II) upon treatment with p-toluenesulfonylhydrazide in methanol. Subsequent reduction of the hydrazone functionality of (II) by means of sodium cyanoborohydride in the presence of p-toluenesulfonic acid furnished the title deoxygenated Adriamycin.
| 【1】 Smith, T.H.; et al.; Adriamycin analogues. 2. Synthesis of 13-deoxyanthracyclines. J Med Chem 1978, 21, 3, 280. |
| 【2】 Olson, R.D.; Zhang, X.; Walsh, G.M. (Gem Pharmaceuticals, Inc.); 13-Deoxyanthracycline derivs. and processes for preparing them. EP 1011687; JP 2001515040; WO 9908687 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11675 | (8S,10S)-10-[[(2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-8-glycoloyl-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydro-5,12-naphthacenedione | C27H29NO11 | 详情 | 详情 | |
| (II) | 51162 | N'-[(Z)-1-((2S,4S)-4-[[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-2-naphthacenyl)-2-hydroxyethylidene]-4-methylbenzenesulfonohydrazide | C34H37N3O12S | 详情 | 详情 |
Extended Information