Methyl-3,5-dimethoxy-4-hydroxybenzoate -Drug Synthesis Database

【结构式】

【分子编号】51024

【品名】Methyl-3,5-dimethoxy-4-hydroxybenzoate

【CA登记号】

【分子式】C₁₀H₁₂O₅

【分子量】212.20228

【元素组成】C 56.6% H 5.7% O 37.7%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

Alkylation of methyl 4-hydroxy-3,5-dimethoxybenzoate (IV) with benzyl bromide afforded the corresponding 4-benzyloxy derivative (V). After basic hydrolysis of the methyl ester group of (V), the resultant carboxylic acid (VI) was converted to acid chloride (VII) using thionyl chloride in refluxing toluene. Then, acylation of diamine (III) with acid chloride (VII) afforded the title amide.

参考文献中间体

合成目标

【1】 Caulfield, W.L.; et al.; The first potent and selective inhibitors of the glycine transporter type 2. J Med Chem 2001, 44, 17, 2679.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(III)	51023	1-(aminomethyl)-N,N-dimethylcyclopentanamine; N-[1-(aminomethyl)cyclopentyl]-N,N-dimethylamine	C₈H₁₈N₂	详情	详情
(IV)	51024	Methyl-3,5-dimethoxy-4-hydroxybenzoate	C₁₀H₁₂O₅	详情	详情
(V)	51025	methyl 4-(benzyloxy)-3,5-dimethoxybenzoate	C₁₇H₁₈O₅	详情	详情
(VI)	51026	4-(benzyloxy)-3,5-dimethoxybenzoic acid	C₁₆H₁₆O₅	详情	详情
(VII)	51027	4-(benzyloxy)-3,5-dimethoxybenzoyl chloride	C₁₆H₁₅ClO₄	详情	详情

Extended Information