1-(dimethylamino)cyclopentanecarbonitrile -Drug Synthesis Database

【结构式】

【分子编号】51022

【品名】1-(dimethylamino)cyclopentanecarbonitrile

【CA登记号】

【分子式】C₈H₁₄N₂

【分子量】138.21264

【元素组成】C 69.52% H 10.21% N 20.27%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

Aminonitrile (II) was prepared by Strecker reaction of cyclopentanone (I) with potassium cyanide and dimethylamine hydrochloride. Subsequent reduction of (II) with alane, generated in situ from LiAlH4 and H2SO4, produced diamine (III).

参考文献中间体

合成目标

【1】 Caulfield, W.L.; et al.; The first potent and selective inhibitors of the glycine transporter type 2. J Med Chem 2001, 44, 17, 2679.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	15113	cyclopentanone	120-92-3	C₅H₈O	详情	详情
(II)	51022	1-(dimethylamino)cyclopentanecarbonitrile		C₈H₁₄N₂	详情	详情
(III)	51023	1-(aminomethyl)-N,N-dimethylcyclopentanamine; N-[1-(aminomethyl)cyclopentyl]-N,N-dimethylamine		C₈H₁₈N₂	详情	详情

Extended Information