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【结 构 式】 
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【分子编号】50858 【品名】3-[2-(dibenzylamino)ethyl]-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one 【CA登记号】 |
【 分 子 式 】C25H29N3O 【 分 子 量 】387.52488 【元素组成】C 77.49% H 7.54% N 10.84% O 4.13% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)The intermediate 3-(2-aminoethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (IV) has been obtained as follows: The condensation of 3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (I) with dibenzylamine (II) by means of NaHCO3 in refluxing acetonitrile gives the tertiary amine (III), which is debenzylated by hydrogenation with H2 over Pd/C in warm ethanol to afford the target intermediate (IV).
| 【1】 Huguet-Clotet, J.; Marquillas Olondriz, F.; Caldero Ges, J.M.; Del Castillo Nieto, J.C.; Dalmases Barjoan, P.; Bosch Rovira, A. (Vita-Invest, SA); Process for obtaining 3-2-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl-2-methyl-6,7,8,9-tetrahydro-4H-pyrido-[1,2-a]pyrimidine-4-one. ES 2074966 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 23044 | 3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one | 63234-80-0 | C11H15ClN2O | 详情 | 详情 |
| (II) | 12361 | N,N-Dibenzylamine; Dibenzylamine; N-Benzyl(phenyl)methanamine | 103-49-1 | C14H15N | 详情 | 详情 |
| (III) | 50858 | 3-[2-(dibenzylamino)ethyl]-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one | C25H29N3O | 详情 | 详情 | |
| (IV) | 50859 | 3-(2-aminoethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one | C11H17N3O | 详情 | 详情 |
Extended Information