N-[2-[3-(1,3-dioxan-2-yl)propyl]-4-quinolinyl]acetamide -Drug Synthesis Database

【结构式】

【分子编号】50857

【品名】N-[2-[3-(1,3-dioxan-2-yl)propyl]-4-quinolinyl]acetamide

【CA登记号】

【分子式】C₁₈H₂₂N₂O₃

【分子量】314.38436

【元素组成】C 68.77% H 7.05% N 8.91% O 15.27%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The condensation of N-(2-methylquinolin-4-yl)acetamide (I) with 2-(2-iodoethyl)-1,3-dioxane (II) by means of LDA in THF gives the corresponding adduct (III), which is then cyclized and deacylated by means of aqueous HCl to afford the target tetrahydroacridine.

参考文献中间体

合成目标

【1】 Caldero Ges, J.M.; Huguet Clotet, J. (Vita-Invest, SA); Process for the preparation of (±)-9-amino-1,2,3,4-tetrahydroacridin-1-ol. ES 2059263 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	50855	N-(2-methyl-4-quinolinyl)acetamide	C₁₂H₁₂N₂O	详情	详情
(II)	50856	2-(2-iodoethyl)-1,3-dioxane	C₆H₁₁IO₂	详情	详情
(III)	50857	N-[2-[3-(1,3-dioxan-2-yl)propyl]-4-quinolinyl]acetamide	C₁₈H₂₂N₂O₃	详情	详情

Extended Information