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【结 构 式】 
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【分子编号】50693 【品名】2-[[(7S)-7-([(2R)-2-[4-(benzyloxy)-3-(2-hydroxyethyl)phenyl]-2-hydroxyethyl]amino)-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]-N,N-dimethylacetamide 【CA登记号】 |
【 分 子 式 】C31H38N2O5 【 分 子 量 】518.6532 【元素组成】C 71.79% H 7.38% N 5.4% O 15.42% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XXV)The silyl protecting groups of (XXIV) were cleaved by acidic treatment yielding diol (XXV). Then, O-benzyl group hydrogenolysis in (XXV) using Pd/C, followed by salification with H2SO4, provided the title compound.
| 【1】 Yanagi, T.; et al.; The practical synthesis of a uterine relaxant, bis (2-{[2S)-2-({(2R)-2-hydroxy-2-[4-hydroxy-3-(2-hydroxyethyl)-phenyl]ethyl}amino)-1,2,3,4-tetrahydronaphthalen-7-yl]oxy}-N,N-dimethylacetamide)sulfate (KUR-1246). Chem Pharm Bull 2001, 49, 8, 1018. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XXIV) | 50692 | 2-([(7S)-7-[((2R)-2-[4-(benzyloxy)-3-(2-[[tert-butyl(dimethyl)silyl]oxy]ethyl)phenyl]-2-[[tert-butyl(dimethyl)silyl]oxy]ethyl)amino]-5,6,7,8-tetrahydro-2-naphthalenyl]oxy)-N,N-dimethylacetamide | C43H66N2O5Si2 | 详情 | 详情 | |
| (XXV) | 50693 | 2-[[(7S)-7-([(2R)-2-[4-(benzyloxy)-3-(2-hydroxyethyl)phenyl]-2-hydroxyethyl]amino)-5,6,7,8-tetrahydro-2-naphthalenyl]oxy]-N,N-dimethylacetamide | C31H38N2O5 | 详情 | 详情 |
Extended Information