benzyl 2-methyl-2-(2-naphthyl)propanoate -Drug Synthesis Database

【结构式】

【分子编号】50659

【品名】benzyl 2-methyl-2-(2-naphthyl)propanoate

【CA登记号】

【分子式】C₂₁H₂₀O₂

【分子量】304.3886

【元素组成】C 82.86% H 6.62% O 10.51%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The precursor 2,2-dimethyl-(2-naphthyl)acetic acid (IV) was prepared as follows. 2-Naphthylacetic acid (I) was converted to the benzyl ester (II) by treatment with benzyl bromide and DBU. Dimethylation of the sodium enolate of (II) with iodomethane furnished (III). Removal of the benzyl ester group of (III) was then achieved by hydrogenolysis in the presence of Pd/C.

参考文献中间体

合成目标

【1】 Betageri, R.; Llinas-Brunet, M.; Moss, N.; Patel, U.; Cardozo, M.; Beaulieu, P.L.; Ferland, J.-M.; Proudfoot, J.R. (Boehringer Ingelheim Pharmaceuticals Inc.); Pyridones as Src family SH2 domain inhibitors. EP 1045836; US 6054470; US 6156784; WO 9931066 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	50657	2-Naphthylacetic acid; beta-Naphthylacetic acid	581-96-4	C₁₂H₁₀O₂	详情	详情
(II)	50658	benzyl 2-(2-naphthyl)acetate		C₁₉H₁₆O₂	详情	详情
(III)	50659	benzyl 2-methyl-2-(2-naphthyl)propanoate		C₂₁H₂₀O₂	详情	详情
(IV)	50660	2-methyl-2-(2-naphthyl)propionic acid		C₁₄H₁₄O₂	详情	详情

Extended Information