ethyl (2E,4E)-3-methyl-5-[(1S,2S)-2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)cyclopropyl]-2,4-pentadienoate -Drug Synthesis Database

【结构式】

【分子编号】50534

【品名】ethyl (2E,4E)-3-methyl-5-[(1S,2S)-2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)cyclopropyl]-2,4-pentadienoate

【CA登记号】

【分子式】C₂₆H₃₆O₂

【分子量】380.57064

【元素组成】C 82.06% H 9.53% O 8.41%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XIII)

Horner-Emmons condensation of aldehyde (XI) with phosphonate (XII) produced the diene ester (XIII). Finally, ethyl ester hydrolysis of (XIII) gave rise to the title carboxylic acid.

参考文献中间体

合成目标

【1】 Vuligonda, V.; et al.; Enantioselective syntheses of potent retinoid X receptor ligands: Differential biological activities of individuals antipodes. J Med Chem 2001, 44, 14, 2298.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(XI)	50533	(1R,2S)-2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)cyclopropanecarbaldehyde		C₁₉H₂₆O	详情	详情
(XII)	44704	ethyl (E)-4-(diethoxyphosphoryl)-3-methyl-2-butenoate	41891-54-7	C₁₁H₂₁O₅P	详情	详情
(XIII)	50534	ethyl (2E,4E)-3-methyl-5-[(1S,2S)-2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)cyclopropyl]-2,4-pentadienoate		C₂₆H₃₆O₂	详情	详情

Extended Information