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【结 构 式】

【分子编号】50518

【品名】Imino bis propylamine; N-(3-Aminopropyl)-1,3-propanediamine; Bis-(3-aminopropyl)amine; Dipropylenetriamine; Dipropylentriamine; 3,3'-Diaminodipropylamine; 3,3'-Iminodipropylamine

【CA登记号】56-18-8

【 分 子 式 】C6H17N3

【 分 子 量 】131.2212

【元素组成】C 54.92% H 13.06% N 32.02%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IX)

In an alternative method, 2,3-bis(benzyloxy)benzoic acid (VII) was activated as the corresponding imidazolide (VIII) prior to condensation with norspermidine (IX). The resulting diamide (X) was further acylated with N-(benzyloxycarbonyl)-D-threonine (II) to afford triamide (XI). Hydrogenolysis of the O-benzyl and N-benzyloxycarbonyl protecting groups of (XI) then gave amino alcohol (V), which was finally cyclized with imidate (VI) as above.

1 Bergeron, R.J.; et al.; Significance of asymmetric sites in choosing siderophores as deferration agents. J Med Chem 2001, 44, 15, 2469.
2 Bergeron, R.J. Jr. (University of Florida); Synthesis of parabactin and homologs thereof. US 4565874 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(II) 43420 (2S,3R)-2-[[(benzyloxy)carbonyl]amino]-3-hydroxybutyric acid 19728-63-3 C12H15NO5 详情 详情
(V) 50514 N-[3-([(2R,3S)-2-amino-3-hydroxybutanoyl][3-[(2,3-dihydroxybenzoyl)amino]propyl]amino)propyl]-2,3-dihydroxybenzamide C24H32N4O8 详情 详情
(VI) 50515 ethyl 2,3-dihydroxybenzenecarboximidoate C9H11NO3 详情 详情
(VII) 50516 2,3-bis(benzyloxy)benzoic acid C21H18O4 详情 详情
(VIII) 50517 [2,3-bis(benzyloxy)phenyl](1H-imidazol-1-yl)methanone C24H20N2O3 详情 详情
(IX) 50518 Imino bis propylamine; N-(3-Aminopropyl)-1,3-propanediamine; Bis-(3-aminopropyl)amine; Dipropylenetriamine; Dipropylentriamine; 3,3'-Diaminodipropylamine; 3,3'-Iminodipropylamine 56-18-8 C6H17N3 详情 详情
(X) 50519 2,3-bis(benzyloxy)-N-[3-[(3-[[2,3-bis(benzyloxy)benzoyl]amino]propyl)amino]propyl]benzamide C48H49N3O6 详情 详情
(XI) 50520 benzyl (1R,2S)-1-[[bis(3-[[2,3-bis(benzyloxy)benzoyl]amino]propyl)amino]carbonyl]-2-hydroxypropylcarbamate C60H62N4O10 详情 详情
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