N-[2-(dimethylamino)ethyl]-9-hydroxy-5,6-dimethyl-6H-pyrido[4,3-b]carbazole-1-carboxamide -Drug Synthesis Database

【结构式】

【分子编号】50481

【品名】N-[2-(dimethylamino)ethyl]-9-hydroxy-5,6-dimethyl-6H-pyrido[4,3-b]carbazole-1-carboxamide

【CA登记号】

【分子式】C₂₂H₂₄N₄O₂

【分子量】376.45832

【元素组成】C 70.19% H 6.43% N 14.88% O 8.5%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The title hemiglutarate ester was synthesized by acylation of the known olivacine derivative (I) with glutaric anhydride (II) in pyridine, followed by conversion to the corresponding dihydrochloride salt.

参考文献中间体

合成目标

【1】 Charton, Y.; Guilbaud, N.; Léonce, S.; Pierré, A.; Guillonneau, C.; Michel, A.; Atassi, G.; Kraus-Berthier, L.; Bisagni, E.; Synthesis of 9-O-substituted derivatives of 9-hydroxy-5, 6-dimethyl-6H-pyrido[4,3-b]carbazole-1-carboxylic acid (2-(dimethylamino)ethyl)amide and their 10- and 11-methyl analogues with improved antitumor activity. J Med Chem 1999, 42, 12, 2191.
【2】 Guilbaud, N.; Bisagni, E.; Guillonneau, C.; Charton, Y.; Atassi, G.; Pierre, A. (ADIR et Cie.); Ellipticine derivs., their preparation and pharmaceutical compsns. containing them. EP 0850940; US 6162811 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	15512	Glutaric Anhydride; dihydro-2H-pyran-2,6(3H)-dione	108-55-4	C₅H₆O₃	详情	详情
(II)	50481	N-[2-(dimethylamino)ethyl]-9-hydroxy-5,6-dimethyl-6H-pyrido[4,3-b]carbazole-1-carboxamide		C₂₂H₂₄N₄O₂	详情	详情

Extended Information