disodium (1S,2R,3S)-1-(1,3-benzodioxol-5-yl)-3-[4-hydroxy-2-[(2S)-2-methyl-3-oxido-3-oxopropyl]phenyl]-2,3-dihydro-1H-indene-2-carboxylate -Drug Synthesis Database

【结构式】

【分子编号】50347

【品名】disodium (1S,2R,3S)-1-(1,3-benzodioxol-5-yl)-3-[4-hydroxy-2-[(2S)-2-methyl-3-oxido-3-oxopropyl]phenyl]-2,3-dihydro-1H-indene-2-carboxylate

【CA登记号】

【分子式】C₂₇H₂₂Na₂O₇

【分子量】504.447016

【元素组成】C 64.29% H 4.4% Na 9.11% O 22.2%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The labeled compound has been obtained by methylation of the phenolic OH of the known compound (L-843974) with 11C-methyl iodide (II) by means of tetrabutylammonium hydroxide in DMF.

参考文献中间体

合成目标

【1】 Ravert, H.T.; et al.; Radiosynthesis of a potent endothelin receptor antagonist: [11C] L-753,037. J Label Compd Radiopharm 2000, 43, 12, 1205.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	50347	disodium (1S,2R,3S)-1-(1,3-benzodioxol-5-yl)-3-[4-hydroxy-2-[(2S)-2-methyl-3-oxido-3-oxopropyl]phenyl]-2,3-dihydro-1H-indene-2-carboxylate		C₂₇H₂₂Na₂O₇	详情	详情

Extended Information