(4aS,6R,8aS)-1-bromo-3-methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol -Drug Synthesis Database

【结构式】

【分子编号】50306

【品名】(4aS,6R,8aS)-1-bromo-3-methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol

【CA登记号】

【分子式】C₁₇H₂₀BrNO₃

【分子量】366.25474

【元素组成】C 55.75% H 5.5% Br 21.82% N 3.82% O 13.11%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The reaction of (-)-galanthamine hydrobromide (I) with H2O2 in formic acid at 100 C gives 8-bromo-(-)galanthamine (II), which is then treated with LiAlD4 and D2O to yield the target deuterated compound.

参考文献中间体

合成目标

【1】 Fels, G.; Linnemann, E.; Synthesis of 3H-(-)-galanthamine. J Label Compd Radiopharm 2001, 44, 9, 661.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	50305	(4aS,6R,8aS)-6-hydroxy-3-methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium bromide		C₁₇H₂₂BrNO₃	详情	详情
(II)	50306	(4aS,6R,8aS)-1-bromo-3-methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol		C₁₇H₂₀BrNO₃	详情	详情

Extended Information