ethyl 3-(4-piperidinyl)propanoate -Drug Synthesis Database

【结构式】

【分子编号】50255

【品名】ethyl 3-(4-piperidinyl)propanoate

【CA登记号】

【分子式】C₁₀H₁₉NO₂

【分子量】185.2664

【元素组成】C 64.83% H 10.34% N 7.56% O 17.27%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Chlorosulfonylation of the benzamidopyrazole (I) to give (II) was performed with neat chlorosulfonic acid at 0 C. Coupling of sulfonyl chloride (II) with the piperidinopropanoate (III) provided sulfonamide (IV). Finally, cyclization of (IV) with concomitant ester hydrolysis under basic conditions furnished the target pyrazolopyrimidine.

参考文献中间体

合成目标

【1】 Kim, D.-K.; et al.; Synthesis and phosphodiesterase inhibitory activity of new sildenafil analogues containing a carboxylic acid group in the 5'-sulfonamide moiety of a phenyl ring. Bioorg Med Chem 2001, 9, 11, 3013.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	50253	1-methyl-4-[(2-propoxybenzoyl)amino]-3-propyl-1H-pyrazole-5-carboxamide	C₁₈H₂₄N₄O₃	详情	详情
(II)	50254	3-([[5-(aminocarbonyl)-1-methyl-3-propyl-1H-pyrazol-4-yl]amino]carbonyl)-4-propoxybenzenesulfonyl chloride	C₁₈H₂₃ClN₄O₅S	详情	详情
(III)	50255	ethyl 3-(4-piperidinyl)propanoate	C₁₀H₁₉NO₂	详情	详情
(IV)	50256	ethyl 3-(1-[[3-([[5-(aminocarbonyl)-1-methyl-3-propyl-1H-pyrazol-4-yl]amino]carbonyl)-4-propoxyphenyl]sulfonyl]-4-piperidinyl)propanoate	C₂₈H₄₁N₅O₇S	详情	详情

Extended Information