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【结 构 式】 
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【分子编号】50232 【品名】2,8-dimethoxy-5-[4-[2-(1-piperidinyl)ethoxy]phenyl]benzo[c]phenanthridin-6(5H)-one 【CA登记号】 |
【 分 子 式 】C32H32N2O4 【 分 子 量 】508.61716 【元素组成】C 75.57% H 6.34% N 5.51% O 12.58% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XIII)Condensation of phenol (X) with N-(2-hydroxyethyl)piperidine (XI) under Mitsunobu conditions furnished ether (XII). The lactam function of (XII) was then reduced with LiAlH4 to produce (XIII). Finally, methyl ether cleavage in (XIII) was carried out by treatment with AlCl3 in the presence of EtSH.
| 【1】 Grese, T.A.; et al.; Photochemical synthesis of N-arylbenzophenanthridine selective estrogen receptor modulators (SERMs). J Med Chem 2001, 44, 17, 2857. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (X) | 50231 | 5-(4-hydroxyphenyl)-2,8-dimethoxybenzo[c]phenanthridin-6(5H)-one | C25H19NO4 | 详情 | 详情 | |
| (XI) | 37675 | 2-(1-piperidinyl)-1-ethanol | 3040-44-6 | C7H15NO | 详情 | 详情 |
| (XII) | 50233 | 4-[2,8-dimethoxybenzo[c]phenanthridin-5(6H)-yl]phenyl 2-(1-piperidinyl)ethyl ether; 2,8-dimethoxy-5-[4-[2-(1-piperidinyl)ethoxy]phenyl]-5,6-dihydrobenzo[c]phenanthridine | C32H34N2O3 | 详情 | 详情 | |
| (XIII) | 50232 | 2,8-dimethoxy-5-[4-[2-(1-piperidinyl)ethoxy]phenyl]benzo[c]phenanthridin-6(5H)-one | C32H32N2O4 | 详情 | 详情 |
Extended Information