5-(tert-butyl)-2-methoxy-N-(4-methoxyphenethyl)benzamide -Drug Synthesis Database

【结构式】

【分子编号】50167

【品名】5-(tert-butyl)-2-methoxy-N-(4-methoxyphenethyl)benzamide

【CA登记号】

【分子式】C₂₁H₂₇NO₃

【分子量】341.45032

【元素组成】C 73.87% H 7.97% N 4.1% O 14.06%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Coupling between ethylamine derivative (I) and acid chloride (II) by means of DMAP in pyridine affords benzamide (III), which is then subjected to reaction with chlorosulfonic acid followed by treatment with aqueous ammonia to provide benzenesulfonamide (IV). Finally, the desired product is obtained by condensation of (IV) with methyl isothiocyanate in DMF by means of K2CO3.

参考文献中间体

合成目标

【1】 Gögelein, H.; Bohn, H.; Heitsch, H.; Englert, H.C.; Gerlach, U.; Wirth, K. (Aventis Pharma Deutschland GmbH); Use of benzenesulfonyl(thio)ureas for the treatment and prophylaxis of dysfunctions of the autonomous nervous system and use of benzenesulfonyl(thio)ureas in combination with beta-receptor blockers. DE 19841534; EP 1117409; WO 0015204 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	48701	1-(p-Methoxyphenyl)ethylamine; 1-Amino-2-(4-methoxyphenyl)ethane; 2-(4-Methoxyphenyl)ethylamine; 4-(2-Aminoethyl)anisole; 4-Methoxybenzeneethanamine; 4-Methoxyphenethylamine; 4-Methoxyphenylethylamine; p-Methoxy phenethylamine; p-Methoxy phenylethylamine	55-81-2	C₉H₁₃NO	详情	详情
(II)	50166	5-(tert-butyl)-2-methoxybenzoyl chloride		C₁₂H₁₅ClO₂	详情	详情
(III)	50167	5-(tert-butyl)-2-methoxy-N-(4-methoxyphenethyl)benzamide		C₂₁H₂₇NO₃	详情	详情
(IV)	50168	N-[3-(aminosulfonyl)-4-methoxyphenethyl]-5-(tert-butyl)-2-methoxybenzamide		C₂₁H₂₈N₂O₅S	详情	详情

Extended Information