【结 构 式】 |
【分子编号】50135 【品名】methyl (2S)-2-[[(5-[[(1H-imidazol-4-ylmethyl)amino]methyl]-2'-methyl[1,1'-biphenyl]-2-yl)carbonyl]amino]-4-(methylsulfanyl)butanoate 【CA登记号】 |
【 分 子 式 】C25H30N4O3S 【 分 子 量 】466.60436 【元素组成】C 64.35% H 6.48% N 12.01% O 10.29% S 6.87% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(IV)Reductive amination of the methionine methyl ester adduct of 2-(2-methylphenyl)-4-aminomethyl benzoic acid (I) with 1-trityl-4-formylimidazole (II) gave the secondary amine (III). After trityl group deprotection, the resultant methyl ester (IV) was hydrolyzed to the target carboxylic acid by using LiOH.
【1】 Blaskovich, M.A.; Hamilton, A.D.; Sun, J.; Knowles, D.; Bailey, R.D.; Sebti, S.M.; Ohkanda, J.; Qian, Y.; Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: Combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine. Cancer Res 1999, 59, 19, 4919. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 50133 | methyl (2S)-2-([[5-(aminomethyl)-2'-methyl[1,1'-biphenyl]-2-yl]carbonyl]amino)-4-(methylsulfanyl)butanoate | C21H26N2O3S | 详情 | 详情 | |
(II) | 27712 | 1-trityl-1H-imidazole-4-carbaldehyde;1-Tritylimidazole-4-carboxaldehyde | 33016-47-6 | C23H18N2O | 详情 | 详情 |
(III) | 50134 | methyl (2S)-4-(methylsulfanyl)-2-([[2'-methyl-5-([[(1-trityl-1H-imidazol-4-yl)methyl]amino]methyl)[1,1'-biphenyl]-2-yl]carbonyl]amino)butanoate | C44H44N4O3S | 详情 | 详情 | |
(IV) | 50135 | methyl (2S)-2-[[(5-[[(1H-imidazol-4-ylmethyl)amino]methyl]-2'-methyl[1,1'-biphenyl]-2-yl)carbonyl]amino]-4-(methylsulfanyl)butanoate | C25H30N4O3S | 详情 | 详情 |
Extended Information