【结 构 式】 |
【分子编号】50107 【品名】2-chloro-3-cyano-6,7-dimethyl-1,4-quinoxalinediiumdiolate 【CA登记号】 |
【 分 子 式 】C11H8ClN3O2 【 分 子 量 】249.65624 【元素组成】C 52.92% H 3.23% Cl 14.2% N 16.83% O 12.82% |
合成路线1
该中间体在本合成路线中的序号:(IX)Acetylation of substituted aniline (I) with acetic anhydride in refluxing acetic acid affords acetanilide (II), which is then nitrated with HNO3:H2SO4 to provide 2-nitro derivative (III). Hydrolysis of (III) in concentrated H2SO4 gives substituted 2-nitroaniline (IV), which is then subjected to diazotization with NaNO2 and HCl in H2O and then treated with NaN3 and sodium acetate in H2O to furnish 2-nitrophenyl azide derivative (V). Cyclocondensation of azide (V) in refluxing toluene yields benzofuroxane (VI), which in turn is subjected to Beirut reaction with malonitrile (VII) in DMF in the presence of Et3N to yield 3-amino-2-quinoxalinecarbonitrile 1,4-di-N-oxide (VIII). The amino group of (VIII) is replaced by chlorine by using tert-butyl nitrite in acetonitrile in the presence of copper (II) chloride to give compound (IX). Finally, the target compound is obtained by reaction of (IX) with 1-(4-nitro-phenyl)piperazine (X) in dichloromethane or CHCl3 in the presence of Na2CO3 or K2CO3.
【1】 Jaso, A.; Montoya, M.E.; Monge, A.; Zarranz, B.; Ortega, M.A.; Tirapu, I.; Aldana, I.; Antimycobacterial activity of new quinoxaline-2-carbonitrile and quinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives. Pharmazie 2001, 56, 3, 205. |
【2】 Monge, A.; et al.; Hypoxia-selective agents derived from quinoxaline 1, 4-di-N-oxides. J Med Chem 1995, 38, 10, 1786. |
【3】 Ortega, M.A.; et al.; New quinoxalinecarbonitrile 1,4-di-N-oxide derivatives as hypoxic-cytotoxic agents. Eur J Med Chem 2000, 35, 1, 21. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 33707 | 3,4-dimethylphenylamine; 3,4-dimethylaniline | 95-64-7 | C8H11N | 详情 | 详情 |
(II) | 50101 | N-Acetyl-3,4-xylidine; 3,4-Dimethylacetanilide | 2198-54-1 | C10H13NO | 详情 | 详情 |
(III) | 50102 | 4',5'-Dimethyl-2'-nitroacetanilide | C10H12N2O3 | 详情 | 详情 | |
(IV) | 50103 | 2-Nitro-4,5-dimethylaniline; 6-Nitro-3,4-xylidine; 4,5-Dimethyl-2-nitroaniline | 6972-71-0 | C8H10N2O2 | 详情 | 详情 |
(V) | 50104 | 1-azido-4,5-dimethyl-2-nitrobenzene | C8H8N4O2 | 详情 | 详情 | |
(VI) | 50105 | 5,6-dimethyl-2,1,3-benzoxadiazol-1-ium-1-olate | C8H8N2O2 | 详情 | 详情 | |
(VII) | 10610 | 2-[(4-Methoxybenzyl)oxy]acetyl chloride | C10H11ClO3 | 详情 | 详情 | |
(VIII) | 50106 | 2-amino-3-cyano-6,7-dimethyl-1,4-quinoxalinediiumdiolate | C11H10N4O2 | 详情 | 详情 | |
(IX) | 50107 | 2-chloro-3-cyano-6,7-dimethyl-1,4-quinoxalinediiumdiolate | C11H8ClN3O2 | 详情 | 详情 | |
(X) | 20299 | 1-(4-nitrophenyl)piperazine | 6269-89-2 | C10H13N3O2 | 详情 | 详情 |