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【结 构 式】 
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【分子编号】49869 【品名】3-(5-hydroxy-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinolin-5-yl)phenyl acetate 【CA登记号】 |
【 分 子 式 】C28H27NO5 【 分 子 量 】457.52612 【元素组成】C 73.51% H 5.95% N 3.06% O 17.48% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XIII)Acylation of (XII) with acetyl chloride and pyridine afforded the phenyl acetate (XIII). Deoxygenation of the tertiary hydroxyl group of (XIII) using triethylsilane and boron trifluoride etherate gave (XIV). After hydrolysis of the acetate ester of (XIV), the resulting phenol (XV) was alkylated with chloromethyl methyl sulfide to furnish the title compound.
| 【1】 Wang, A.X.; Kym, P.R.; Jones, T.K.; Kort, M.E.; Edwards, J.P.; Moore, J.L.; Elmore, S.W.; Coughlan, M.J.; Pratt, J.K. (Abbott Laboratories Inc.; Ligand Pharmaceuticals, Inc.); Glucocorticoid-selective anti-inflammatory agents. EP 1053239; WO 9941256 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XII) | 49868 | 5-(3-hydroxyphenyl)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinolin-5-ol | C26H25NO4 | 详情 | 详情 | |
| (XIII) | 49869 | 3-(5-hydroxy-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinolin-5-yl)phenyl acetate | C28H27NO5 | 详情 | 详情 | |
| (XIV) | 49870 | 3-(10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinolin-5-yl)phenyl acetate | C28H27NO4 | 详情 | 详情 | |
| (XV) | 49871 | 3-(10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinolin-5-yl)phenol | C26H25NO3 | 详情 | 详情 |
Extended Information