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【结 构 式】 
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【分子编号】49856 【品名】5-[(E)-2-bromoethenyl]-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-2,4(1H,3H)-pyrimidinedione 【CA登记号】 |
【 分 子 式 】C11H13BrN2O5 【 分 子 量 】333.1387 【元素组成】C 39.66% H 3.93% Br 23.99% N 8.41% O 24.01% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The title compound was synthesized by coupling 5-(bromovinyl)-2'-deoxyuridine (I) with phenyl L-methoxyalanino phosphoroamidate (II) in the presence of imidazole in DMF.
| 【1】 Vaino, A.R.; Lobl, T.J.; Baehr, D.N.; Lehsten, D.M.; An improved procedure for the synthesis of nucleoside phosphoramidates. Org Process Res Dev 2002, 6, 6, 819. |
| 【2】 Shepard, H.M. (NewBiotics, Inc.); Enzyme catalyzed therapeutic agents. EP 1167972; JP 2001220397; US 6245750; WO 9937753 . |
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