4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-1-[3-(4-fluorophenoxy)propyl]-3-methoxypyridinium iodide -Drug Synthesis Database

【结构式】

【分子编号】49577

【品名】4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-1-[3-(4-fluorophenoxy)propyl]-3-methoxypyridinium iodide

【CA登记号】

【分子式】C₂₃H₂₄ClFIN₃O₄

【分子量】587.8169532

【元素组成】C 47% H 4.12% Cl 6.03% F 3.23% I 21.59% N 7.15% O 10.89%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The title compound has been obtained by hydrogenation of 4-(4-amino-5-chloro-2-methoxybenzamido)-1-[3-(4-fluorophenoxy)propyl]-3-methoxypyridinium iodide (I) with H2 over PtO2 in methanol, or with NaBH4 and RhCl3 or NiCl2 in methanol.

参考文献中间体

合成目标

【1】 Caldero Ges, J.M.; Huguet Clotet, J.; Process for obtaining cis-4-amino-5-chloro-2-methoxy-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]benzamide. ES 2019234 .
【2】 Huguet Clotet, J.; Caldero Ges, J.M.; Process for obtaining cis-4-amino-5-chloro-2-methoxy-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]benzamide. ES 2020128 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	49577	4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-1-[3-(4-fluorophenoxy)propyl]-3-methoxypyridinium iodide		C₂₃H₂₄ClFIN₃O₄	详情	详情

Extended Information