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【结 构 式】

【分子编号】49148

【品名】2-(Methylthio)aniline; o-Aminothioanisole; o-Thioanisidine; 2-Aminothioanisole; 2-Methylmercaptoaniline; o-(methylthio)aniline

【CA登记号】2987-53-3

【 分 子 式 】C7H9NS

【 分 子 量 】139.2212

【元素组成】C 60.39% H 6.52% N 10.06% S 23.03%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

2-(Methylthio)aniline (I) was alkylated with 2-(chloromethyl)-2-imidazoline hydrochloride (II) in phenol at 120 C to afford the condensation product (III). Subsequent oxidation of the thioether functionality of (III) with m-chloroperbenzoic acid gave rise to the target sulfone.

1 Hodson, S.J.; Navas, F. III; Bishop, M.J.; Bigham, E.C.; Garrison, D.T.; Drewry, D.H.; Speake, J.D. (Glaxo Group Ltd.); Imidazoline derivs. as alpha-1A adrenoceptor ligands. WO 0066563 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 49148 2-(Methylthio)aniline; o-Aminothioanisole; o-Thioanisidine; 2-Aminothioanisole; 2-Methylmercaptoaniline; o-(methylthio)aniline 2987-53-3 C7H9NS 详情 详情
(II) 17330 2-(chloromethyl)-4,5-dihydro-1H-imidazole C4H7ClN2 详情 详情
(III) 49149 N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-N-[2-(methylsulfanyl)phenyl]amine; N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2-(methylsulfanyl)aniline C11H15N3S 详情 详情
Extended Information