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【结 构 式】 
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【分子编号】49118 【品名】5-[([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-4-cyano-3-methyl-1-phenyl-1H-pyrazole 【CA登记号】 |
【 分 子 式 】C18H14ClN5O3S 【 分 子 量 】415.85976 【元素组成】C 51.99% H 3.39% Cl 8.53% N 16.84% O 11.54% S 7.71% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)The known 5-amino-4-cyano-1-phenylpyrazole (I) was coupled with 4-chlorobenzenesulfonyl isocyanate (II) to produce the sulfonyl urea (III). This compound was converted to the corresponding sodium salt by evaporation of its solution in aqueous NaOH.
| 【1】 Hasegawa, H.; et al.; Synthesis of endothelin converting enzyme inhibitors and their structure activity relationships. 21st Symp Med Chem (Nov 28 2001, Kyoto) 2001, Abst 1P-21. |
| 【2】 Matsushita, K.; Hasegawa, H.; Kuribayashi, Y.; Ohashi, N. (Sumitomo Pharmaceuticals Co., Ltd.); Sulfonylureidopyrazole derivs.. EP 0885890; JP 1998007658; WO 9730978 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 49117 | 5-amino-3-methyl-1-phenyl-1H-pyrazole-4-carbonitrile | C11H10N4 | 详情 | 详情 | |
| (II) | 28973 | 4-chlorobenzenesulfonyl isocyanate | 5769-15-3 | C7H4ClNO3S | 详情 | 详情 |
| (III) | 49118 | 5-[([[(4-chlorophenyl)sulfonyl]amino]carbonyl)amino]-4-cyano-3-methyl-1-phenyl-1H-pyrazole | C18H14ClN5O3S | 详情 | 详情 |
Extended Information