2-(2-hydroxyphenyl)-4H-1,3-benzoxazin-4-one -Drug Synthesis Database

【结构式】

【分子编号】49109

【品名】2-(2-hydroxyphenyl)-4H-1,3-benzoxazin-4-one

【CA登记号】

【分子式】C₁₄H₉NO₃

【分子量】239.2304

【元素组成】C 70.29% H 3.79% N 5.85% O 20.06%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Cyclization of salicylamide (I) with salicyloyl chloride (II) by heating at 170 oC provides 2-(2-hydroxyphenyl)-benz[e][1,3]oxazin-4-one (III), which is finally cyclized with 4-hydrazinobenzoic acid (IV) in refluxing ethanol.

参考文献中间体

合成目标

【1】 Lattmann, R.; Acklin, P. (Novartis AG); Substd. 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators. EP 0914118; JP 2000507601; WO 9749395 .
【2】 McIntyre, J.A., Castaner, J., Mealy, N.E., Bayes, M.; Deferasirox. Drugs Fut 2004, 29 (4): 331

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	14652	salicylamide	65-45-2	C₇H₇NO₂	详情	详情
(II)	32668	2-hydroxybenzoyl chloride		C₇H₅ClO₂	详情	详情
(III)	49109	2-(2-hydroxyphenyl)-4H-1,3-benzoxazin-4-one		C₁₄H₉NO₃	详情	详情
(IV)	49110	4-Carboxyphenyl hydrazine; p-Hydrazinobenzoic acid; p-Carboxyphenyl hydrazine; 4-Hydrazinobenzoic acid	619-67-0	C₇H₈N₂O₂	详情	详情

Extended Information