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【结 构 式】 
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【分子编号】49083 【品名】N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)benzamide 【CA登记号】 |
【 分 子 式 】C17H14F3NO2 【 分 子 量 】321.2989096 【元素组成】C 63.55% H 4.39% F 17.74% N 4.36% O 9.96% |
合成路线1
该中间体在本合成路线中的序号：(XV)Acylation of phenylalanine (XI) with benzoyl chloride (XII) under Schotten-Baumann conditions produced the corresponding benzamide (XIII). The cyclization of benzoylphenylalanine (XIII) in the presence of acetic anhydride afforded oxazolone (XIV), which was then reacted with trifluoroacetic anhydride producing the trifluoromethyl ketone (XV). After ketone (XV) reduction to carbinol (XVI) with NaBH4, the acidic hydrolysis of the benzamido group of (XVI) yielded the amino alcohol (XVII) (1). Condensation of acid (X) with amine (XVII) using EDC and HOBt gave amide (XVIII). The hydroxyl group of (XVIII) was then oxidized to ketone (XIX) employing a modified Pfitzner-Moffatt oxidation. Finally, hydrogenolysis of the benzyloxycarbonyl group of (XIX) furnished the desired aminopyrimidinone.
| 【1】 Akahoshi, F.; Ashimori, A.; Yoshimura, T.; et al.; Non-peptidic inhibitors of human chymase. Synthesis, structure-activity relationships, and pharmacokinetic profiles of a series of 5-amino-6-oxo-1,6-dihydropyrimidine-containing trifluoromethyl ketones. Bioorg Med Chem 2001, 9, 2, 301. |
| 【2】 Akahoshi, F.; Yoshimura, T.; Eda, M.; Ashimori, A.; Fukuyama, H.; Nakajima, M.; Imada, T.; Okunishi, H.; Miyazaki, M. (Welfide Corporation); Heterocyclic amide cpds. and medicinal use of the same. EP 0826671; US 5948785; WO 9633974 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (X) | 49080 | 2-[5-[[(benzyloxy)carbonyl]amino]-2-(4-fluorophenyl)-6-oxo-1(6H)-pyrimidinyl]acetic acid | C20H16FN3O5 | 详情 | 详情 | |
| (XI) | 26219 | Phenylalanine | 150-30-1 | C9H11NO2 | 详情 | 详情 |
| (XII) | 10463 | Benzoyl chloride | 98-88-4 | C7H5ClO | 详情 | 详情 |
| (XIII) | 49081 | N-Benzoyl-DL-phenylalanine | 2901-76-0 | C16H15NO3 | 详情 | 详情 |
| (XIV) | 49082 | 4-Benzyl-2-phenyl-2-oxazolin-5-one | 5874-61-3 | C16H13NO2 | 详情 | 详情 |
| (XV) | 49083 | N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)benzamide | C17H14F3NO2 | 详情 | 详情 | |
| (XVI) | 49084 | N-(1-benzyl-3,3,3-trifluoro-2-hydroxypropyl)benzamide | C17H16F3NO2 | 详情 | 详情 | |
| (XVII) | 49085 | 3-amino-1,1,1-trifluoro-4-phenyl-2-butanol | C10H12F3NO | 详情 | 详情 | |
| (XVIII) | 49086 | benzyl 1-[2-[(1-benzyl-3,3,3-trifluoro-2-hydroxypropyl)amino]-2-oxoethyl]-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-5-pyrimidinylcarbamate | C30H26F4N4O5 | 详情 | 详情 | |
| (XIX) | 49087 | benzyl 1-[2-[(1-benzyl-3,3,3-trifluoro-2-oxopropyl)amino]-2-oxoethyl]-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-5-pyrimidinylcarbamate | C30H24F4N4O5 | 详情 | 详情 |