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【结 构 式】 
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【分子编号】49064 【品名】[[(2Z,9E)-11-((3R,5R)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]cyclohexylidene)-5,5-dimethyl-1,1-bis(trifluoromethyl)-2,9-undecadienyl]oxy](trimethyl)silane; (2Z,9E)-11-((3R,5R)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]cyclohexylidene)-5,5-dimethyl-1,1-bis(trifluoromethyl)-2,9-undecadienyl trimethylsilyl ether 【CA登记号】 |
【 分 子 式 】C36H66F6O3Si3 【 分 子 量 】745.1651592 【元素组成】C 58.03% H 8.93% F 15.3% O 6.44% Si 11.31% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XIX)The condensation of aldehyde (XVII) with the chiral phosphinoxide (XVIII) by means of BuLi in THF gives the silylated precursor (XIX), which is finally treated with TBAF in THF.
| 【1】 Mohr, P.; Barbier, P.; Pirson, W.; Muller, M.; Bauer, F. (F. Hoffmann-La Roche AG); Cyclohexanediole derivs.. EP 1056716; WO 9943646 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XVII) | 49063 | (Z)-10,10,10-trifluoro-5,5-dimethyl-9-(trifluoromethyl)-9-[(trimethylsilyl)oxy]-7-decenal | C16H26F6O2Si | 详情 | 详情 | |
| (XVIII) | 30302 | [2-((3R,5R)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]cyclohexylidene)ethyl](oxo)diphenylphosphorane; 2-((3R,5R)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]cyclohexylidene)ethyl(diphenyl)phosphine oxide | C32H51O3PSi2 | 详情 | 详情 | |
| (XIX) | 49064 | [[(2Z,9E)-11-((3R,5R)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]cyclohexylidene)-5,5-dimethyl-1,1-bis(trifluoromethyl)-2,9-undecadienyl]oxy](trimethyl)silane; (2Z,9E)-11-((3R,5R)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]cyclohexylidene)-5,5-dimethyl-1,1-bis(trifluoromethyl)-2,9-undecadienyl trimethylsilyl ether | C36H66F6O3Si3 | 详情 | 详情 |
Extended Information