• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】49019

【品名】ethyl (-)-(1R,2S,4S,6S,7S)-7-fluoro-5-oxo-3-oxatricyclo[4.1.0.0(2,4)]heptane-7-carboxylate

【CA登记号】

【 分 子 式 】C9H9FO4

【 分 子 量 】200.1664632

【元素组成】C 54% H 4.53% F 9.49% O 31.97%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(-)-(XII)

Alternatively, intermediate (1R,2S,5R,6S)-(XIX) can also be obtained by first separation of the isomeric mixture (±)-(X) by chiral HPLC to provide isomer (+)-(X), which is then subjected to the same process described for (±)-(X) in Scheme 28677701a to furnish the desired compound (1R,2S,5R,6S)-(XIX).

2 Kumagai, T.; Sakagami, K.; Nakazato, A.; Tomisawa, K. (Taisho Pharmaceutical Co., Ltd.); 6-Fluorobicyclo[3.1.0]hexane derivs.. EP 1110943; JP 2000336071; WO 0012464 .
1 Nakazato, A.; et al.; Synthesis, SAR, and biological activities of potent and selective group II mGluR agonists, novel 2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives. 220th ACS Natl Meet (Aug 20 2000, Washington DC) 2000, Abst MEDI 104.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(rac)-(X) 49005 ethyl (rac)-(1S*,5S*,6S*)-6-fluoro-2-oxobicyclo[3.1.0]hexane-6-carboxylate C9H11FO3 详情 详情
(+)-(X) 49017 ethyl (+)-(1S,5S,6S)-6-fluoro-2-oxobicyclo[3.1.0]hexane-6-carboxylate C9H11FO3 详情 详情
(+)-(XI) 49018 ethyl (+)-(1S,5S,6S)-6-fluoro-4-oxobicyclo[3.1.0]hex-2-ene-6-carboxylate C9H9FO3 详情 详情
(-)-(XII) 49019 ethyl (-)-(1R,2S,4S,6S,7S)-7-fluoro-5-oxo-3-oxatricyclo[4.1.0.0(2,4)]heptane-7-carboxylate C9H9FO4 详情 详情
(-)-(XIII) 49020 ethyl (-)-(1R,2R,5S,6S)-6-fluoro-2-hydroxy-4-oxobicyclo[3.1.0]hexane-6-carboxylate C9H11FO4 详情 详情
(-)-(XV) 49021   C11H15FO3S2 详情 详情
(-)-(XVI) 49022   C11H13FO3S2 详情 详情
(R,S,R,S)(XVII) 49023   C11H11FN2O4S2 详情 详情
(XIV) 27313 1,2-ethanedithiol 540-63-6 C2H6S2 详情 详情
(XVIII) 10039 (1R)-1-Phenylethylamine; (1R)-1-Phenyl-1-ethanamine.; L-alpha-Phenylethylamine 3886-69-9 C8H11N 详情 详情
(XIX) 49012   C19H20FN3O3S2 详情 详情
Extended Information