|
【结 构 式】 
|
【分子编号】55919 【品名】7-{4-[4-(chloromethyl)benzyl]-1-piperazinyl}-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid 【CA登记号】 |
【 分 子 式 】C25H25ClFN3O3 【 分 子 量 】469.9430232 【元素组成】C 63.9% H 5.36% Cl 7.54% F 4.04% N 8.94% O 10.21% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)The alkylation of ciprofloxacin (I) with bis(chloromethyl)benzene (II) afforded the monosubstituted adduct (III). This was further condensed with norfloxacin (IV) to yield the title heterodimer compound.
| 【1】 Grucz, R.G.; Kerns, R.J.; Kaatz, G.W.; Vaka, F.; Rybak, M.J.; Synthesis and antibacterial activity of novel piperazinyl-linked fluoroquinolones. 41st Intersci Conf Antimicrob Agents Chemother (Dec 16 2001, Chicago) 2001, Abst F-565. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 22103 | 1-cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid | 85721-33-1 | C17H18FN3O3 | 详情 | 详情 |
| (II) | 55918 | 1,4-Bis(chloromethyl)benzene; alpha,alpha'-Dichloro-p-xylene; p-Xylylene dichloride | 623-25-6 | C8H8Cl2 | 详情 | 详情 |
| (III) | 55919 | 7-{4-[4-(chloromethyl)benzyl]-1-piperazinyl}-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid | C25H25ClFN3O3 | 详情 | 详情 | |
| (IV) | 11290 | 1-Ethyl-6-fluoro-4-oxo-7-piperazino-1,4-dihydro-3-quinolinecarboxylic acid; Norfloxacin | 70458-96-7 | C16H18FN3O3 | 详情 | 详情 |
Extended Information