3-{[4-phenyl-3,6-dihydro-1(2H)-pyridinyl]carbonyl}cyclohexanone -Drug Synthesis Database

【结构式】

【分子编号】54944

【品名】3-{[4-phenyl-3,6-dihydro-1(2H)-pyridinyl]carbonyl}cyclohexanone

【CA登记号】

【分子式】C₁₈H₂₁NO₂

【分子量】283.37028

【元素组成】C 76.3% H 7.47% N 4.94% O 11.29%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Racemic amide (VI) was also prepared by a closely related procedure. Coupling of keto acid (XII) with tetrahydropyridine (V) using DCC gave keto amide (XIII), which was then protected as the ethylene ketal (VI) upon treatment with 2-methoxy-1,3-dioxolane (XIV) in the presence of methanesulfonic acid.

参考文献中间体

合成目标

【1】 Wright, J.L.; et al.; The discovery and structure-activity relationships of 1,2,3, 6-tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine autoreceptor agonists and potential antipsychotic agents. J Med Chem 1994, 37, 21, 3523.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	54943	3-oxocyclohexanecarboxylic acid		C₇H₁₀O₃	详情	详情
(II)	13002	4-Phenyl-1,2,3,6-tetrahydropyridine; 1,2,3,6-Tetrahydro-4-phenyl-pyridine	10338-69-9	C₁₁H₁₃N	详情	详情
(III)	54944	3-{[4-phenyl-3,6-dihydro-1(2H)-pyridinyl]carbonyl}cyclohexanone		C₁₈H₂₁NO₂	详情	详情
(IV)	54945	2-Methoxy-1,3-dioxolane	19693-75-5	C₄H₈O₃	详情	详情
(V)	54957	3-(4-morpholinyl)-1-propanol		C₇H₁₅NO₂	详情	详情

Extended Information