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【结 构 式】 
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【分子编号】48868 【品名】ethyl 1-hydrazinecarbimidothioate 【CA登记号】 |
【 分 子 式 】C3H9N3S 【 分 子 量 】119.19068 【元素组成】C 30.23% H 7.61% N 35.25% S 26.9% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(III)Treatment of thiosemicarbazide hydrobromide (I) with ethyl bromide (II) in refluxing EtOH affords S-ethylthiosemicarbazide (III), which is then condensed with N-acetyl-ethylenediamine (IV) in refluxing EtOH to provide N1-(2-acetamidoethyl)-N3-aminoguanidine (V). Finally, the desired product is obtained by the formation of the corresponding hydrochloride salt by treatment of (V) with HCl in methanol. Alternatively the target compound can be obtained by reaction of N-acetylethylenediamine (IV) with cyanogen chloride in 2-propanol followed by treatment with anhydrous hydrazine.
| 【1】 Wagle, D.R.; Ulrich, P.C. (Alteon Inc.); N-Acylaminoalkyl-hydrazinecarboximidamides. US 5877217 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 12954 | 1-Hydrazinecarbothioamide; Thiosemicarbazide | 79-19-6 | CH5N3S | 详情 | 详情 |
| (II) | 30344 | 1-bromoethane；ethyl bromide | 74-96-4 | C2H5Br | 详情 | 详情 |
| (III) | 48868 | ethyl 1-hydrazinecarbimidothioate | C3H9N3S | 详情 | 详情 | |
| (IV) | 41136 | N-(2-aminoethyl)acetamide | 1001-53-2 | C4H10N2O | 详情 | 详情 |
| (V) | 48869 | N-(2-[[hydrazino(imino)methyl]amino]ethyl)acetamide | C5H13N5O | 详情 | 详情 |
Extended Information