合成路线1

Alternatively, the desired compound can be obtained as follows: Treatment of diethyl cyanomethyl phosphonate (VII) with NaH in dimethoxyethane (DME) followed by reaction with 3,3'-difluorobenzophenone (VIII) gives alkene derivative (IX), which is then hydrogenated over Pd(OH)2 to provide compound (X). Reduction of the cyano moiety of (X) by means of B2H6-THF followed by treatment with refluxing HCl yields substituted propylamine (XI), which is then converted into formamide (XIII) by treatment with refluxing ethyl formate (XII). Compound (XIII) is then reduced by means of borane-methyl sulfide in refluxing THF and finally treated with HCl. Propylamine (XI) can also be obtained following these steps: Treatment of benzophenone derivative (VIII) with n-BuLi and acetonitrile in THF affords cyano derivative (XIV), which is then hydrogenated over Ni/Al and NaOH in EtOH to furnish amine (XV). Elimination of the tertiary alcohol (XV) by refluxing with HCl in EtOH gives substituted diphenylpropenamine hydrochloride (XVI), which is hydrogenated over Pd/C in EtOH and finally subjected to hydrochloride salt neutralization.