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【结 构 式】 
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【分子编号】48808 【品名】 【CA登记号】 |
【 分 子 式 】C26H36N2O3 【 分 子 量 】424.58352 【元素组成】C 73.55% H 8.55% N 6.6% O 11.3% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XX)The reaction of aldol (XVII) with Ms-Cl and TEA in dichloromethane gives the mesylate (XVIII), which is treated with tBu-OK in THF to obtain the unsaturated amide (XIX). The reduction of the amide group of (XIX) with AlH3 in ethyl ether yields the corresponding unsaturated enamine (XX), which is finally deprotected by treatment with HCl in acetone.
| 【1】 Basak, A.; Wardrop, D.J.; N-methoxy-N-acylnitrenium ions: Application to the formal synthesis of (-)-TAN1251A. Org Lett 2001, 3, 7, 1053. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XVII) | 19020 | (1R,4S)-4-[1-Hydroxy-1-[4-(3-methyl-2-butenyloxy)phenyl]methyl]-2-methyldispiro[2,5-diazabicyclo[3,2,1]octane-6,1'-cyclohexane-4',2''-[1,3]-dioxolan]-3-one | C26H36N2O5 | 详情 | 详情 | |
| (XVIII) | 19021 | (1R,4S)-4-[1-(Methanesulfonyloxy)-1-[4-(3-methyl-2-butenyloxy)phenyl]methyl]-2-methyldispiro[2,5-diazabicyclo[3,2,1]octane-6,1'-cyclohexane-4',2''-[1,3]-dioxolan]-3-one | C27H38N2O7S | 详情 | 详情 | |
| (XIX) | 48807 | C26H34N2O4 | 详情 | 详情 | ||
| (XX) | 48808 | C26H36N2O3 | 详情 | 详情 |
Extended Information