N-[2-hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl]-1-methyl-1H-indole-5-carboxamide -Drug Synthesis Database

【结构式】

【分子编号】48622

【品名】N-[2-hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl]-1-methyl-1H-indole-5-carboxamide

【CA登记号】

【分子式】C₂₁H₂₄N₂O₅

【分子量】384.43204

【元素组成】C 65.61% H 6.29% N 7.29% O 20.81%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VIII)

In a closely related procedure, amino alcohol (III) was coupled with 1-methyl-5-indolecarboxylic acid (VII) to afford amide (VIII). This was then cyclized to the target oxazoline by using the Burgess reagent.

参考文献中间体

合成目标

【1】 Liu, G.; Jae, H.-S.; Szczepankiewicz, B.G.; et al.; New antimitotic agents with activity in multi-drug-resistant cell lines and in vivo efficacy in murine tumor models. J Med Chem 2001, 44, 25, 4416.
【2】 Sorensen, B.K.; Liu, G.; Tasker, A.S.; et al.; Antimitotic agents with activity in multidrug-resistant tumor cell lines. 221st ACS Natl Meet (April 1 2001, San Diego) 2001, Abst MEDI 139.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(III)	48617	2-amino-1-(3,4,5-trimethoxyphenyl)-1-ethanol	C₁₁H₁₇NO₄	详情	详情
(VII)	48621	1-methyl-1H-indole-5-carboxylic acid	C₁₀H₉NO₂	详情	详情
(VIII)	48622	N-[2-hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl]-1-methyl-1H-indole-5-carboxamide	C₂₁H₂₄N₂O₅	详情	详情

Extended Information