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【结 构 式】

【分子编号】48615

【品名】ethyl 3-[4-(2-isopropyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]-3-oxopropanoate

【CA登记号】

【 分 子 式 】C20H21N3O3

【 分 子 量 】351.40516

【元素组成】C 68.36% H 6.02% N 11.96% O 13.66%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(VII)

Palladium-catalyzed coupling of 3-bromopyridine (I) with propargyl alcohol (II) produced 3-(3-pyridyl)propargyl alcohol (III). Reaction of alcohol (III) with diketene (IV) in the presence of DMAP gave the acetoacetate ester (V), which was subsequently treated with ammonia in THF to furnish the enamino ester (VI). The title dihydropyridine derivative was then obtained by Hantzsch's synthesis upon condensation between ethyl 4-(2-isopropylimidazo[4,5-c]pyridin-1-yl)benzoylacetate (VII), enamino ester (VI) and 3,3-diphenylpropanal in refluxing EtOH.

1 Tasaka, S.; Omori, H.; Tanabe, H.; Gomi, N.; Kiue, A. (Nikken Chemicals Co., Ltd.); 1,4-Dihydropyridine derivs.. EP 1055672; JP 2000044559; US 6306853; WO 9941250 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 13255 methyl 3-[((1R,2E,4Z)-1-[(S)-hydroxy[3-(2-trityl-2H-1,2,3,4-tetraazol-5-yl)phenyl]methyl]-2,4-tetradecadienyl)sulfanyl]propanoate C45H52N4O3S 详情 详情
(II) 16664 Propargyl Alcohol; 2-propyn-1-ol 107-19-7 C3H4O 详情 详情
(III) 48612 3-(3-pyridinyl)-2-propyn-1-ol C8H7NO 详情 详情
(IV) 11367 4-Methylene-2-oxetanone; Acetyl ketene 674-82-8 C4H4O2 详情 详情
(V) 48613 3-(3-pyridinyl)-2-propynyl 3-oxobutanoate C12H11NO3 详情 详情
(VI) 48614 3-(3-pyridinyl)-2-propynyl (E)-3-amino-2-butenoate C12H12N2O2 详情 详情
(VII) 48615 ethyl 3-[4-(2-isopropyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]-3-oxopropanoate C20H21N3O3 详情 详情
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