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【结 构 式】 
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【分子编号】48492 【品名】 【CA登记号】 |
【 分 子 式 】C40H52FeN2O5 【 分 子 量 】696.70836 【元素组成】C 68.96% H 7.52% Fe 8.02% N 4.02% O 11.48% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XVb)In an improved synthesis, condensation of the beta-dimethyltetramethylene-ferrocene derivative (XIV) with aldehyde (II) produced the unseparable C-20 epimeric mixture (XV) without appreciable amounts of diastereomeric byproducts. Cleavage of the chiral auxiliary group with HOAc under milder conditions furnished the secondary amines (XVI) with minimal C-3,C-7 epimerization. Benzylation of amines (XVI) then gave the enantiomerically pure tertiary amines (XIII), which were finally processed as above.
| 【1】 Kuehne, M.E.; et al.; Enantioselective syntheses of coronaridine and 18-methoxycoronaridine. Tetrahedron 2001, 57, 11, 2085. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XVIa) | 48486 | methyl (3aS,4R,11bR)-4-[(2R)-2-(1,3-dioxolan-2-yl)-4-methoxybutyl]-2,3,3a,4,5,7-hexahydro-1H-pyrrolo[2,3-d]carbazole-6-carboxylate | C24H32N2O5 | 详情 | 详情 | |
| (XVIb) | 48487 | methyl (3aS,4R,11bR)-4-[(2S)-2-(1,3-dioxolan-2-yl)-4-methoxybutyl]-2,3,3a,4,5,7-hexahydro-1H-pyrrolo[2,3-d]carbazole-6-carboxylate | C24H32N2O5 | 详情 | 详情 | |
| (XIIIa) | 48488 | methyl (3aS,4R,11bR)-3-benzyl-4-[(2R)-2-(1,3-dioxolan-2-yl)-4-methoxybutyl]-2,3,3a,4,5,7-hexahydro-1H-pyrrolo[2,3-d]carbazole-6-carboxylate | C31H38N2O5 | 详情 | 详情 | |
| (XIIIb) | 48489 | methyl (3aS,4R,11bR)-3-benzyl-4-[(2S)-2-(1,3-dioxolan-2-yl)-4-methoxybutyl]-2,3,3a,4,5,7-hexahydro-1H-pyrrolo[2,3-d]carbazole-6-carboxylate | C31H38N2O5 | 详情 | 详情 | |
| (XVa) | 48491 | C40H52FeN2O5 | 详情 | 详情 | ||
| (XVb) | 48492 | C40H52FeN2O5 | 详情 | 详情 | ||
| (II) | 48474 | 4-(1,3-dioxolan-2-yl)-6-methoxyhexanal | C10H18O4 | 详情 | 详情 | |
| (XIV) | 48490 | C30H36FeN2O2 | 详情 | 详情 |
Extended Information