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【结 构 式】 
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【分子编号】48389 【品名】3-[4-(2-pyridinyl)-3,6-dihydro-1(2H)-pyridinyl]-1-propanamine; 3-[4-(2-pyridinyl)-3,6-dihydro-1(2H)-pyridinyl]propylamine 【CA登记号】 |
【 分 子 式 】C13H19N3 【 分 子 量 】217.31408 【元素组成】C 71.85% H 8.81% N 19.34% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XIV)In an alternative method, 2,4'-dipyridyl (XI) was alkylated with 3-bromopropylamine hydrobromide (VII) in hot DMF to provide the pyridinium salt (XII). Reduction of (XII) with NaBH4 gave the tetrahydropyridine (XIII), which was further hydrogenated in the presence of Pearlman's catalyst to yield the intermediate pyridylpiperidine (X).
| 【1】 O'Malley, S.S.; Chen, T.-B.; Chang, R.S.L.; et al.; In vitro studies on L-771,688 (SNAP 6383), a new potent and selective alpha1A-adrenoceptor antagonist. Eur J Pharmacol 2000, 409, 3, 301. |
| 【2】 Ikemoto, N.; Taylor, C.S.; Sidler, D.R.; Chartrain, M.; Bills, G.F.; Roberge, C.M.; Li, W.; Larsen, R.D. (Merck & Co., Inc.); alpha 1a Adrenergic receptor antagonist. WO 9907695 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (X) | 48387 | 3-[4-(2-pyridinyl)-1-piperidinyl]propylamine; 3-[4-(2-pyridinyl)-1-piperidinyl]-1-propanamine | C13H21N3 | 详情 | 详情 | |
| (XI) | 36311 | 2,4'-Dipyridyl | 581-47-5 | C10H8N2 | 详情 | 详情 |
| (XII) | 25449 | 3-bromo-1-propanamine; 3-bromopropylamine | 18370-81-5 | C3H8BrN | 详情 | 详情 |
| (XIII) | 48388 | 1-(3-aminopropyl)-4-(2-pyridinyl)pyridinium bromide | C13H16BrN3 | 详情 | 详情 | |
| (XIV) | 48389 | 3-[4-(2-pyridinyl)-3,6-dihydro-1(2H)-pyridinyl]-1-propanamine; 3-[4-(2-pyridinyl)-3,6-dihydro-1(2H)-pyridinyl]propylamine | C13H19N3 | 详情 | 详情 |
Extended Information