2-((1R)-1-[[(2-[(1R)-1-[([2-[(1R)-1-aminoethyl]-5-methyl-1,3-oxazol-4-yl]carbonyl)amino]-2-methylpropyl]-1,3-thiazol-4-yl)carbonyl]amino]ethyl)-1,3-thiazole-4-carboxylic acid -Drug Synthesis Database

【结构式】

【分子编号】48378

【品名】2-((1R)-1-[[(2-[(1R)-1-[([2-[(1R)-1-aminoethyl]-5-methyl-1,3-oxazol-4-yl]carbonyl)amino]-2-methylpropyl]-1,3-thiazol-4-yl)carbonyl]amino]ethyl)-1,3-thiazole-4-carboxylic acid

【CA登记号】

【分子式】C₂₁H₂₆N₆O₅S₂

【分子量】506.60688

【元素组成】C 49.79% H 5.17% N 16.59% O 15.79% S 12.66%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XXIV)

The intermediate acid (VI) was then coupled to amine (XXI) to furnish (XXII). Sequential deprotection of the ethyl ester and the N-Boc protecting groups of (XXII) produced the linear precursor (XXIV). This was finally cyclized to the title compound using DPPA.

参考文献中间体

合成目标

【1】 Xia, Z.; Smith, C.D.; Total synthesis of dendroamide A, a novel cyclic peptide that reverses multiple drug resistance. J Org Chem 2001, 66, 10, 3459.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(VI)	48363	2-[(1R)-1-[(tert-butoxycarbonyl)amino]ethyl]-5-methyl-1,3-oxazole-4-carboxylic acid	C₁₂H₁₈N₂O₅	详情	详情
(XXI)	48374	ethyl 2-[(1R)-1-[([2-[(1R)-1-amino-2-methylpropyl]-1,3-thiazol-4-yl]carbonyl)amino]ethyl]-1,3-thiazole-4-carboxylate	C₁₆H₂₂N₄O₃S₂	详情	详情
(XXII)	48376	ethyl 2-[(1R)-1-([[2-((1R)-1-[[(2-[(1R)-1-[(tert-butoxycarbonyl)amino]ethyl]-5-methyl-1,3-oxazol-4-yl)carbonyl]amino]-2-methylpropyl)-1,3-thiazol-4-yl]carbonyl]amino)ethyl]-1,3-thiazole-4-carboxylate	C₂₈H₃₈N₆O₇S₂	详情	详情
(XXIII)	48377	2-[(1R)-1-([[2-((1R)-1-[[(2-[(1R)-1-[(tert-butoxycarbonyl)amino]ethyl]-5-methyl-1,3-oxazol-4-yl)carbonyl]amino]-2-methylpropyl)-1,3-thiazol-4-yl]carbonyl]amino)ethyl]-1,3-thiazole-4-carboxylic acid	C₂₆H₃₄N₆O₇S₂	详情	详情
(XXIV)	48378	2-((1R)-1-[[(2-[(1R)-1-[([2-[(1R)-1-aminoethyl]-5-methyl-1,3-oxazol-4-yl]carbonyl)amino]-2-methylpropyl]-1,3-thiazol-4-yl)carbonyl]amino]ethyl)-1,3-thiazole-4-carboxylic acid	C₂₁H₂₆N₆O₅S₂	详情	详情

Extended Information