ethyl 2-((1R)-1-[[(2-[(1R)-1-[(tert-butoxycarbonyl)amino]-2-methylpropyl]-1,3-thiazol-4-yl)carbonyl]amino]ethyl)-1,3-thiazole-4-carboxylate -Drug Synthesis Database

【结构式】

【分子编号】48373

【品名】ethyl 2-((1R)-1-[[(2-[(1R)-1-[(tert-butoxycarbonyl)amino]-2-methylpropyl]-1,3-thiazol-4-yl)carbonyl]amino]ethyl)-1,3-thiazole-4-carboxylate

【CA登记号】

【分子式】C₂₁H₃₀N₄O₅S₂

【分子量】482.62516

【元素组成】C 52.26% H 6.27% N 11.61% O 16.58% S 13.29%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XX)

The thiazole amino acid (XIX) was prepared by a similar method as above, consisting of conversion of N-Boc-D-valine (XIV) to the corresponding amide (XV) followed by thionation to (XVI). Condensation of thioamide (XVI) with ethyl bromopyruvate (X) and subsequent acid dehydration gave thiazole (XVIII). Basic hydrolysis of the ethyl ester group of (XVIII) then gave acid (XIX). Coupling of the N-Boc-amino acid (XIX) with aminoester (XIII) produced the corresponding amide (XX). Further acid cleavage of the Boc protecting group gave (XXI).

参考文献中间体

合成目标

【1】 Xia, Z.; Smith, C.D.; Total synthesis of dendroamide A, a novel cyclic peptide that reverses multiple drug resistance. J Org Chem 2001, 66, 10, 3459.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(X)	25183	ethyl 3-bromo-2-oxopropanoate;ethyl 3-bromopyruvate;Bromopyruvic acid ethyl ester;ethyl 3-bromopyruvate;ethyl bromopyruvate	70-23-5	C₅H₇BrO₃	详情	详情
(XIII)	48367	ethyl 2-[(1R)-1-aminoethyl]-1,3-thiazole-4-carboxylate		C₈H₁₂N₂O₂S	详情	详情
(XIV)	48375	(2R)-2-[(tert-butoxycarbonyl)amino]-3-methylbutyric acid		C₁₀H₁₉NO₄	详情	详情
(XV)	48368	tert-butyl (1R)-1-(aminocarbonyl)-2-methylpropylcarbamate		C₁₀H₂₀N₂O₃	详情	详情
(XVI)	48369	tert-butyl (1R)-1-(aminocarbothioyl)-2-methylpropylcarbamate		C₁₀H₂₀N₂O₂S	详情	详情
(XVII)	48370	ethyl 2-[(1R)-1-[(tert-butoxycarbonyl)amino]-2-methylpropyl]-4-hydroxy-4,5-dihydro-1,3-thiazole-4-carboxylate		C₁₅H₂₆N₂O₅S	详情	详情
(XVIII)	48371	ethyl 2-[(1R)-1-[(tert-butoxycarbonyl)amino]-2-methylpropyl]-1,3-thiazole-4-carboxylate		C₁₅H₂₄N₂O₄S	详情	详情
(XIX)	48372	2-[(1R)-1-[(tert-butoxycarbonyl)amino]-2-methylpropyl]-1,3-thiazole-4-carboxylic acid		C₁₃H₂₀N₂O₄S	详情	详情
(XX)	48373	ethyl 2-((1R)-1-[[(2-[(1R)-1-[(tert-butoxycarbonyl)amino]-2-methylpropyl]-1,3-thiazol-4-yl)carbonyl]amino]ethyl)-1,3-thiazole-4-carboxylate		C₂₁H₃₀N₄O₅S₂	详情	详情
(XXI)	48374	ethyl 2-[(1R)-1-[([2-[(1R)-1-amino-2-methylpropyl]-1,3-thiazol-4-yl]carbonyl)amino]ethyl]-1,3-thiazole-4-carboxylate		C₁₆H₂₂N₄O₃S₂	详情	详情

Extended Information