(2S)-2-(bromomethyl)oxirane -Drug Synthesis Database

【结构式】

【分子编号】48333

【品名】(2S)-2-(bromomethyl)oxirane

【CA登记号】

【分子式】C₃H₅BrO

【分子量】136.9761

【元素组成】C 26.31% H 3.68% Br 58.33% O 11.68%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

Reaction of 3-(4-hydroxyphenyl)propionic acid (I) with the chiral dioxolanylmethyl chloride (II) afforded the corresponding dioxolanylmethyl ester (III). The phenolic hydroxyl group of (III) was then alkylated with (S)-bromohydrin (IV) to produce the intermediate (V).

参考文献中间体

合成目标

【1】 Iguchi, S.; Kawamura, M.; Miyamoto, T. (Ono Pharmaceutical Co., Ltd.); Novel esters of phenylalkanoic acid. EP 0397031; JP 1991072475; JP 1994073044; US 5013734 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	25691	3-(4-hydroxyphenyl)propionic acid	501-97-3	C₉H₁₀O₃	详情	详情
(II)	45778	(4S)-4-(chloromethyl)-2,2-dimethyl-1,3-dioxolane	60456-22-6	C₆H₁₁ClO₂	详情	详情
(III)	48332	[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-(4-hydroxyphenyl)propanoate		C₁₅H₂₀O₅	详情	详情
(IV)	48333	(2S)-2-(bromomethyl)oxirane		C₃H₅BrO	详情	详情
(V)	48334	[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-[4-[(2S)oxiranylmethoxy]phenyl]propanoate		C₁₈H₂₄O₆	详情	详情

Extended Information