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【结 构 式】

【分子编号】48299

【品名】3-methyl-4-phenyl-2-quinolinecarbonyl chloride

【CA登记号】

【 分 子 式 】C17H12ClNO

【 分 子 量 】281.74112

【元素组成】C 72.47% H 4.29% Cl 12.58% N 4.97% O 5.68%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

Friedländer cyclization between 2-aminobenzophenone (I) and 2-oxobutyric acid (II) by means of NaOMe in MeOH gives carboxylic acid (III), which is then converted into the corresponding acid chloride (IV) by reaction with SOCl2 in CH2Cl2. Finally, the target product is obtained by reaction of (IV) with N-methylbenzylamine (V) by means of Et3N.

1 Anzini, M.; et al.; Synthesis of 2-substituted 2,3-dihydro-9-phenyl-1H-pyrrolo[3,4-b]quinolin-3-ones as potential peripheral benzodiazepine-receptor ligands. Heterocycles 1994, 38, 1, 103.
2 Manzoni, C.; Anzini, M.; Cappelli, A.; Giorgi, G.; Menziani, M.C.; Vomero, S.; De Benedetti, P.G.; Mapping the peripheral benzodiazepine receptor binding site by conformationally restrained derivatives of 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide (PK11195). J Med Chem 1997, 40, 18, 2910.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 21101 (2-aminophenyl)(phenyl)methanone; 2-Aminobenzophenone 2835-77-0 C13H11NO 详情 详情
(II) 48297 2-oxobutyric acid 600-18-0 C4H6O3 详情 详情
(III) 48298 3-methyl-4-phenyl-2-quinolinecarboxylic acid C17H13NO2 详情 详情
(IV) 48299 3-methyl-4-phenyl-2-quinolinecarbonyl chloride C17H12ClNO 详情 详情
(V) 11969 N-Methyl(phenyl)methanamine; N-Benzyl-N-methylamine; N-Methylbenzylamine 103-67-3 C8H11N 详情 详情
Extended Information