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【结 构 式】 
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【分子编号】48221 【品名】4-[(3-fluorobenzyl)oxy]benzaldehyde 【CA登记号】 |
【 分 子 式 】C14H11FO2 【 分 子 量 】230.2385432 【元素组成】C 73.03% H 4.82% F 8.25% O 13.9% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)Safinamide has been obtained by reductocondensation of 4-(3-fluorobenzyloxy)benzaldehyde (I) with L-alaninamide (II) by means of sodium cyanoborohydride in methanol.
| 【1】 Sorbera, L.A.; Castaner, J.; Leeson, P.A.; Safinamide mesilate. Drugs Fut 2001, 26, 8, 745. |
| 【2】 Bonsignori, A.; Pevarello, P.; Dostert, P.; et al.; Synthesis and anticonvulsant activity of a new class of 2-[arylalkyl)amino]alkanamide derivatives. J Med Chem 1998, 41, 4, 579. |
| 【3】 Dostert, P.; Pevarello, P.; Heidempergher, F.; Varasi, M.; Bonsignori, A.; Roncucci, R. (Pharmacia Corp.); N-Phenylalkyl substd. alpha-amino carboxamide derivs. and process for their preparation. EP 0400495; EP 0426816; JP 1992500215; US 5236957; US 5391577; US 5502079; WO 9014334 . |
| 【4】 Dostert, P.; Pevarello, P.; Bonsignori, A.; Varasi, M.; Synthesis and anticonvulsant activity of new benzyloxybenzylacetamide derivatives. 12th Int Symp Med Chem (Sept 13-17, Basel) 1992, Abst P-089.C. |
Extended Information