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【结 构 式】

【分子编号】48172

【品名】Kyselina Undecylenova; n-Undecylenic acid; 10-Henedecenoic acid; Undec-10-enoic acid; 10-Hendecenoic acid; Undecyl-10-enic acid; 10-Hendecenoic; 9-Undecylenic acid; 10-Undecylenic acid; 10-undecenoic acid

【CA登记号】112-38-9

【 分 子 式 】C11H20O2

【 分 子 量 】184.2786

【元素组成】C 71.7% H 10.94% O 17.36%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(VI)

In an alternative synthesis, (S)-3-(tert-butoxycarbonylamino)glutarimide (IV) was deprotected by means of trifluoroacetic acid to yield the aminoglutarimide (V). BOP-mediated coupling of (V) with 10-undecenoic acid (VI) then gave the target amide.

1 Fox, D.J.; Grainger, D.J.; Reckless, J.; Warren, S.G.; Design, synthesis, and preliminary pharmacological evaluation of N-acyl-3-aminoglutarimides as broad-spectrum chemokine inhibitors in vitro and anti-inflammatory agents in vivo. J Med Chem 2002, 45, 2, 360.
2 Grainger, D.J.; Tatalick, L.M. (NeoRx Corp.); Cpds. and methods to inhibit or augment an inflammatory response. WO 0042071 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(IV) 27696 tert-butyl (3S)-2,6-dioxopiperidinylcarbamate C10H16N2O4 详情 详情
(V) 48171 (3S)-3-amino-2,6-piperidinedione C5H8N2O2 详情 详情
(VI) 48172 Kyselina Undecylenova; n-Undecylenic acid; 10-Henedecenoic acid; Undec-10-enoic acid; 10-Hendecenoic acid; Undecyl-10-enic acid; 10-Hendecenoic; 9-Undecylenic acid; 10-Undecylenic acid; 10-undecenoic acid 112-38-9 C11H20O2 详情 详情
Extended Information