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【结 构 式】 
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【分子编号】48096 【品名】(E)-3-[4-[2-(dimethylamino)ethoxy]phenyl]-2-propenoyl chloride 【CA登记号】 |
【 分 子 式 】C13H16ClNO2 【 分 子 量 】253.72828 【元素组成】C 61.54% H 6.36% Cl 13.97% N 5.52% O 12.61% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(II)4-(2-Dimethylaminoethoxy)cinnamic acid (I) was converted to acid chloride (II) upon treatment with thionyl chloride in refluxing benzene. This was then coupled with the sodium alkoxide of fumagillol (III) in THF to furnish the title compound.
| 【1】 Chun, H.S.; Choi, N.S.; Lee, S.J.; Han, C.K.; Hong, C.I.; Hong, R.K.; Kim, J.W.; Moon, S.K.; Ahn, S.K. (Chong Kun Dang Corp.); Fumagillol derivs. and processes for preparing the same. US 6063812; WO 9959986 . |
| 【1】 Kim, J.W., Ahn, S.K., Hong, R.K. et al. (Chong Kun Dang Holdings Corp.) Fumagillol derivatives and processes for preparing the same. CA 2331873, EP 1077964, JP 2002515497, US 6063812, WO 1999059986. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 48095 | (E)-3-[4-[2-(dimethylamino)ethoxy]phenyl]-2-propenoic acid | C13H17NO3 | 详情 | 详情 | |
| (I) | 13712 | (3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]octan-6-ol | C16H26O4 | 详情 | 详情 | |
| (II) | 48096 | (E)-3-[4-[2-(dimethylamino)ethoxy]phenyl]-2-propenoyl chloride | C13H16ClNO2 | 详情 | 详情 | |
| (II) | 48096 | (E)-3-[4-[2-(dimethylamino)ethoxy]phenyl]-2-propenoyl chloride | C13H16ClNO2 | 详情 | 详情 | |
| (III) | 13712 | (3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]octan-6-ol | C16H26O4 | 详情 | 详情 | |
| (III) | 48095 | (E)-3-[4-[2-(dimethylamino)ethoxy]phenyl]-2-propenoic acid | C13H17NO3 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(II)4-(2-Dimethylaminoethoxy)cinnamic acid (I) was converted to acid chloride (II) upon treatment with thionyl chloride in refluxing benzene. This was then coupled with the sodium alkoxide of fumagillol (III) in THF to furnish the title compound.
| 【1】 Chun, H.S.; Choi, N.S.; Lee, S.J.; Han, C.K.; Hong, C.I.; Hong, R.K.; Kim, J.W.; Moon, S.K.; Ahn, S.K. (Chong Kun Dang Corp.); Fumagillol derivs. and processes for preparing the same. US 6063812; WO 9959986 . |
| 【1】 Kim, J.W., Ahn, S.K., Hong, R.K. et al. (Chong Kun Dang Holdings Corp.) Fumagillol derivatives and processes for preparing the same. CA 2331873, EP 1077964, JP 2002515497, US 6063812, WO 1999059986. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 48095 | (E)-3-[4-[2-(dimethylamino)ethoxy]phenyl]-2-propenoic acid | C13H17NO3 | 详情 | 详情 | |
| (I) | 13712 | (3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]octan-6-ol | C16H26O4 | 详情 | 详情 | |
| (II) | 48096 | (E)-3-[4-[2-(dimethylamino)ethoxy]phenyl]-2-propenoyl chloride | C13H16ClNO2 | 详情 | 详情 | |
| (II) | 48096 | (E)-3-[4-[2-(dimethylamino)ethoxy]phenyl]-2-propenoyl chloride | C13H16ClNO2 | 详情 | 详情 | |
| (III) | 13712 | (3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]octan-6-ol | C16H26O4 | 详情 | 详情 | |
| (III) | 48095 | (E)-3-[4-[2-(dimethylamino)ethoxy]phenyl]-2-propenoic acid | C13H17NO3 | 详情 | 详情 |
Extended Information