tert-butyl 2-[5-[([2'-[(tert-butylamino)sulfonyl]-3-fluoro[1,1'-biphenyl]-4-yl]amino)carbonyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzylcarbamate -Drug Synthesis Database

【结构式】

【分子编号】47967

【品名】tert-butyl 2-[5-[([2'-[(tert-butylamino)sulfonyl]-3-fluoro[1,1'-biphenyl]-4-yl]amino)carbonyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzylcarbamate

【CA登记号】

【分子式】C₃₃H₃₅F₄N₅O₅S

【分子量】689.7312128

【元素组成】C 57.47% H 5.11% F 11.02% N 10.15% O 11.6% S 4.65%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XII)

Coupling of acid chloride (X) with the biphenyl amine (XI) gave the corresponding amide (XII). The tert-butyl and Boc protecting groups of (XII) were finally cleaved by treatment with trifluoroacetic acid.

参考文献中间体

合成目标

【1】 Bostrom, L.L.; Pinto, D.J.P.; Galemmo, R.A. Jr.; Rossi, K.A. (DuPont Pharmaceuticals Co.); Nitrogen containing heteroaromatics with ortho-substd. P1's as factor Xa inhibitors. EP 1042299; WO 9932454 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(X)	47965	tert-butyl 2-[5-(chlorocarbonyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzylcarbamate	C₁₇H₁₇ClF₃N₃O₃	详情	详情
(XI)	47966	4'-amino-N-(tert-butyl)-3'-fluoro[1,1'-biphenyl]-2-sulfonamide	C₁₆H₁₉FN₂O₂S	详情	详情
(XII)	47967	tert-butyl 2-[5-[([2'-[(tert-butylamino)sulfonyl]-3-fluoro[1,1'-biphenyl]-4-yl]amino)carbonyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzylcarbamate	C₃₃H₃₅F₄N₅O₅S	详情	详情

Extended Information